LETC is an orally active α-synuclein (α-Syn) aggregation inhibitor, demonstrating an EC50 of 66 nM in transfected DH60.21 neuroblastoma cells. This compound effectively crosses the blood-brain barrier, making it suitable for in vivo studies. LETC is valuable for researching synucleinopathies and understanding the mechanisms of neurodegenerative diseases associated with α-Syn aggregation.
LETC is an orally active α-synuclein (α-Syn) aggregation inhibitor, demonstrating an EC50 of 66 nM in transfected DH60.21 neuroblastoma cells. This compound effectively crosses the blood-brain barrier, making it suitable for in vivo studies. LETC is valuable for researching synucleinopathies and understanding the mechanisms of neurodegenerative diseases associated with α-Syn aggregation.
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