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Phospholipids, mainly glycerophospholipids, form cell membrane bilayers and give rise to lipid signaling mediators. Each glycerophospholipid carries fatty acyl or ether-linked chains on a glycerol backbone and a phosphate-containing head group. Egg phosphatidylcholines, a natural mixture of phosphatidylcholine species, are commonly used to prepare model membranes and vesicles. sn-Glycero-3-phosphocholine is the deacylated backbone of phosphatidylcholine and a water-soluble metabolite of choline metabolism. Oxidized phospholipids such as POVPC arise when polyunsaturated acyl chains in membranes and lipoproteins are oxidized. 2-O-Methyl PAF C-16 is an ether lipid analog of platelet-activating factor (PAF). A few compounds, such as the nucleotide 5-PA-dUTP, are phosphate-containing reagents rather than phospholipids.
1,2-Dilinoleoyl phosphatidylinositol serves as a substrate for Phosphatidylinositol-4-phosphate 5-kinase (PI4P5K) isoforms α, β, and γ. This phosphatidylinositol derivative is essential in studying PI4P5K activity in vitro, contributing to our understanding of signaling pathways involving phosphoinositides. Its application extends to research on lipid metabolism and membrane dynamics in cellular processes.
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18:1 PE-Benzylguanine ammonium is a lipid that serves as a reactive substrate for SNAP-tag protein labeling. This compound facilitates the covalent attachment of proteins to lipid membranes, enabling the study of protein localization and dynamics in live cells. It is particularly useful in applications such as cellular imaging, protein tracking, and the investigation of lipid-protein interactions.
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Synonyms: 1-Octanoyl-sn-glycero-3-phosphocholine
08:0 Lyso PC (1-Octanoyl-sn-glycero-3-phosphocholine) is a lysolecithin that serves as a substrate for Phospholipase A2 enzymatic activity. This compound is utilized in studies focusing on lipid metabolism and membrane dynamics, as well as investigations into inflammatory processes. Its hydrolysis by Phospholipase A2 makes it valuable for research into signaling pathways and cell membrane composition.
