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Sphingolipids

Sphingolipids are membrane lipids built on a sphingoid base, with ceramide as their central intermediate. In cells, serine and palmitoyl-coenzyme A condense into sphingoid bases, which are then N-acylated to ceramides and extended into sphingomyelin and glycosphingolipids. Ceramides of defined chain length are represented by C6 Ceramide, C8-Ceramide and C24:1-Ceramide, which differ in how they partition into membranes. Glycosphingolipids include Cerebroside B, N-Acetylpsychosine and Ganglioside GT1b (bovine) ammonium, a sialylated ganglioside of neuronal membranes. Compounds directed at the biosynthetic enzymes are listed as well, among them the sphingomyelin synthase inhibitor malabaricone C and the sphingosine kinase inhibitor SKI-I.

Cat. No.

A30052

CAS No.

124753-97-5

C6 Ceramide

Synonyms: C6-Cer; N-Hexanoylsphingosine

C6 Ceramide is a short-chain, cell-permeable ceramide pathway activator that exhibits significant anticancer activity. It enhances miR-29b expression, influencing the progression of multiple myeloma by inhibiting endothelial cell proliferation, migration, and angiogenesis through the Akt signaling pathway. C6 Ceramide demonstrates a range of anti-cancer effects, including cell cycle arrest, induction of apoptosis, and tumor growth inhibition, and can serve as an adjuvant to improve the effectiveness of chemotherapy in drug-resistant cancer cells.

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1 mg

$25.00

2 mg

$30.00

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Cat. No.

A65539

CAS No.

752987-57-8

Biotinylated sphingosine

Synonyms: Biotinyl-Sph

Biotinylated sphingosine is a substrate for sphingosine kinase, primarily targeting SPHK1 and SPHK2. This compound enables the detection of sphingosine kinase phosphorylation activity, making it a valuable tool for studies focused on sphingolipid metabolism and signal transduction pathways. Researchers can leverage biotinylated sphingosine in various applications, including enzyme activity assays and the exploration of sphingosine-related cellular processes.

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0.05 mg

$290.00

All 1 sizes

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