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Sphingolipids

Sphingolipids are membrane lipids built on a sphingoid base, with ceramide as their central intermediate. In cells, serine and palmitoyl-coenzyme A condense into sphingoid bases, which are then N-acylated to ceramides and extended into sphingomyelin and glycosphingolipids. Ceramides of defined chain length are represented by C6 Ceramide, C8-Ceramide and C24:1-Ceramide, which differ in how they partition into membranes. Glycosphingolipids include Cerebroside B, N-Acetylpsychosine and Ganglioside GT1b (bovine) ammonium, a sialylated ganglioside of neuronal membranes. Compounds directed at the biosynthetic enzymes are listed as well, among them the sphingomyelin synthase inhibitor malabaricone C and the sphingosine kinase inhibitor SKI-I.

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  • cis-4-Methylsphingosine
    Cat. No.
    B20701
    CAS No.
    1407154-31-7

    cis-4-Methylsphingosine

    Cis-4-Methylsphingosine is a synthetic analogue of sphingosine that functions as a modulator of sphingosine-1-phosphate receptors. It exhibits key biological activities related to cell signaling, particularly influencing pathways involved in cell proliferation and survival. This compound is utilized in research applications focused on lipid signaling, inflammation, and cancer biology, making it a valuable tool for studying the roles of sphingolipids in various physiological processes.

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