Sphingolipids

Sphingolipids are membrane lipids built on a sphingoid base, with ceramide as their central intermediate. In cells, serine and palmitoyl-coenzyme A condense into sphingoid bases, which are then N-acylated to ceramides and extended into sphingomyelin and glycosphingolipids. Ceramides of defined chain length are represented by C6 Ceramide, C8-Ceramide and C24:1-Ceramide, which differ in how they partition into membranes. Glycosphingolipids include Cerebroside B, N-Acetylpsychosine and Ganglioside GT1b (bovine) ammonium, a sialylated ganglioside of neuronal membranes. Compounds directed at the biosynthetic enzymes are listed as well, among them the sphingomyelin synthase inhibitor malabaricone C and the sphingosine kinase inhibitor SKI-I.

2 Items

  • C6 Ceramide
    Cat. No.
    A30052

    C6 Ceramide

    Synonyms: C6-Cer; N-Hexanoylsphingosine

    C6 Ceramide is a short-chain, cell-permeable ceramide pathway activator that exhibits significant anticancer activity. It enhances miR-29b expression, influencing the progression of multiple myeloma by inhibiting endothelial cell proliferation, migration, and angiogenesis through the Akt signaling pathway. C6 Ceramide demonstrates a range of anti-cancer effects, including cell cycle arrest, induction of apoptosis, and tumor growth inhibition, and can serve as an adjuvant to improve the effectiveness of chemotherapy in drug-resistant cancer cells.

    1 mg
    $25.00
    2 mg
    $30.00
    All 7 sizes
  • cis-4-Methylsphingosine
    Cat. No.
    B20701

    cis-4-Methylsphingosine

    Cis-4-Methylsphingosine is a synthetic analogue of sphingosine that functions as a modulator of sphingosine-1-phosphate receptors. It exhibits key biological activities related to cell signaling, particularly influencing pathways involved in cell proliferation and survival. This compound is utilized in research applications focused on lipid signaling, inflammation, and cancer biology, making it a valuable tool for studying the roles of sphingolipids in various physiological processes.

    Out of stock

    All 3 sizes

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