Fig. 1 · Structure
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Lp(a)-IN-5 hydrochloride
Lp(a) Inhibitor
Lp(a)-IN-5 hydrochloride is a potent lipoprotein (a) (Lp(a)) inhibitor that functions by disrupting the assembly of Apo(a) and ApoB proteins, exhibiting an IC50 value of 0.41 nM. This compound is utilized in research focused on diseases associated with elevated plasma Lp(a) levels, such as various cardiovascular disorders. Its oral bioavailability further enhances its applicability in preclinical studies aimed at understanding the role of Lp(a) in pathophysiology.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2924841-80-3 |
| Applications | Lp(a) Inhibitor |
| Formula | C43H60Cl4N4O7 |
| Molecular Weight | 886.77 |
| SMILES | O=C(O)[C@H]([C@H]1CCNC1)CC2=CC=CC(CN(CC3=CC(C[C@H](C(O)=O)[C@H]4CCNC4)=CC=C3)CCOC5=CC(C[C@H](C(O)=O)[C@H]6CCNC6)=CC=C5)=C2.Cl.Cl.Cl.Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.