Fig. 1 · Structure

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Lp(a)-IN-5

Lp(a) Inhibitor.

Lp(a)-IN-5 is an orally bioavailable inhibitor of lipoprotein (a) (Lp(a)), specifically targeting the assembly of apolipoprotein(a) (Apo(a)) and apolipoprotein B (ApoB). With an IC50 value of 0.41 nM, Lp(a)-IN-5 demonstrates potent inhibitory activity, making it a valuable tool for investigating conditions associated with elevated plasma Lp(a) levels, particularly in the context of cardiovascular diseases. Its efficacy in disrupting Lp(a) formation highlights its potential for further research into therapeutic interventions for related disorders.

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Specifications

Manufacturer Adooq Bioscience
Actions Inhibitor
CAS Number 2924841-79-0
Applications Lp(a) Inhibitor.
Formula C43H56N4O7
Molecular Weight 740.93
SMILES
O=C(O)[C@H]([C@H]1CCNC1)CC2=CC=CC(CN(CC3=CC(C[C@H](C(O)=O)[C@H]4CCNC4)=CC=C3)CCOC5=CC(C[C@H](C(O)=O)[C@H]6CCNC6)=CC=C5)=C2

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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