LY164846 is an orally active cephalosporin antibiotic that primarily targets Haemophilus influenzae, exhibiting high sensitivity to both typical and ampicillin-resistant strains, with an MIC90 ≤ 4 μg/mL. The compound also demonstrates significant activity against Methicillin-resistant Staphylococcus aureus and Streptococcus species (excluding Enterococcus), with MIC90 values ranging from 0.25 to 8 μg/mL, and shows moderate sensitivity towards anaerobic bacteria. Its bactericidal properties are indicated by an MBC/MIC ratio of ≤ 2 against Haemophilus influenzae. LY164846 is valuable for investigating respiratory and skin infections in biomedical research.
LY164846 is an orally active cephalosporin antibiotic that primarily targets Haemophilus influenzae, exhibiting high sensitivity to both typical and ampicillin-resistant strains, with an MIC90 ≤ 4 μg/mL. The compound also demonstrates significant activity against Methicillin-resistant Staphylococcus aureus and Streptococcus species (excluding Enterococcus), with MIC90 values ranging from 0.25 to 8 μg/mL, and shows moderate sensitivity towards anaerobic bacteria. Its bactericidal properties are indicated by an MBC/MIC ratio of ≤ 2 against Haemophilus influenzae. LY164846 is valuable for investigating respiratory and skin infections in biomedical research.
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