Search by product name, CAS, target or catalog number. Press Down Arrow to reach product suggestions, Tab to move between links, and Escape to close suggestions.
Activator protein-1 (AP-1) modulators are research compounds associated with Jun and Fos transcription factors. These proteins form dimers that regulate gene expression in response to cellular signals. Their activity is studied in proliferation, differentiation and stress responses. SR 11302 and PNRI-299 are listed as AP-1 inhibitors, while nidulal is listed as an activator. The category therefore brings together compounds with different functional annotations for investigating transcriptional regulation, rather than a single uniform inhibitor class.
FOSL1 Degrader 1 (4) is a potent T-5224-based PROTAC that selectively degrades FOSL1 (AP-1), suppressing cancer stemness gene expression in head and neck squamous cell carcinoma (HNSCC). It effectively inhibits tumor growth and eliminates cancer stem cells, showing 30–100 times greater efficacy than T-5224.
