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Biological Activity
MC-VC-PABC-DNA31 is a drug-linker conjugate for ADC with potent antitumor activity by using DNA31 (a potent RNA polymerase inhibitor), linked via the ADC linker MC-VC-PABC.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 6.69 mL | 33.43 mL | 66.86 mL |
| 0.5 mM | 1.34 mL | 6.69 mL | 13.37 mL |
| 1 mM | 0.67 mL | 3.34 mL | 6.69 mL |
| 5 mM | 0.13 mL | 0.67 mL | 1.34 mL |
*The above data is based on the productmolecular weight 1495.62. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A18511 |
|---|---|
| CAS No. | 1639352-03-6 |
| Formula | C77H94N10O21 |
| M. Wt | 1495.62 |
| Purity | >98% |
| SMILES | O=C([[email protected]](CCCNC(N)=O)NC([[email protected]](C(C)C)NC(CCCCCN1C(C=CC1=O)=O)=O)=O)NC2=CC=C(COC(NC3CCN(C4=CC(OC(C5=N6)=C(NC(/C(C)=C\C=C\[[email protected]](C)[[email protected]]([O])[[email protected]@H](C)[[email protected]@H](O)[[email protected]@H](C)[[email protected]](OC(C)=O)[[email protected]](C)[[email protected]@H](OC)/C=C/O7)=O)C(C8=C([O])C(C)=C(O[[email protected]@]7(C)C9=O)C9=C85)=O)=C6C(O)=C4)CC3)=O)C=C2 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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