ME-1228 is a sulfur-containing analog of OCP 9-176, functioning as a potent antibacterial agent. It demonstrates enhanced activity, being approximately twofold more effective than its precursor against a range of bacteria, including Escherichia coli, Klebsiella pneumoniae, Klebsiella oxytoca, Providencia stuartii, Proteus vulgaris, and Serratia marcescens. Additionally, ME-1228 exhibits significant antibacterial activity against E. coli UB 1005 and Pseudomonas aeruginosa strains, with minimum inhibitory concentrations (MICs) of 0.25 μg/mL for both E. coli UB 1005 and P. aeruginosa K779K, and 1 μg/mL for P. aeruginosa E4. This compound is valuable for research into bacterial resistance mechanisms and the development of new antimicrobial therapies.
ME-1228 is a sulfur-containing analog of OCP 9-176, functioning as a potent antibacterial agent. It demonstrates enhanced activity, being approximately twofold more effective than its precursor against a range of bacteria, including Escherichia coli, Klebsiella pneumoniae, Klebsiella oxytoca, Providencia stuartii, Proteus vulgaris, and Serratia marcescens. Additionally, ME-1228 exhibits significant antibacterial activity against E. coli UB 1005 and Pseudomonas aeruginosa strains, with minimum inhibitory concentrations (MICs) of 0.25 μg/mL for both E. coli UB 1005 and P. aeruginosa K779K, and 1 μg/mL for P. aeruginosa E4. This compound is valuable for research into bacterial resistance mechanisms and the development of new antimicrobial therapies.
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