Me-Tet-PEG5-NHS is an ADC linker designed to facilitate site-specific conjugation through its Tetrazine moiety. This compound can engage in a selective inverse electron demand Diels-Alder (iEDDA) reaction with trans-cyclooctene (TCO) derivatives, enabling the formation of stable linkages in antibody-drug conjugates (ADCs). Its five PEG units enhance solubility and promote improved pharmacokinetics, making it suitable for targeted drug delivery applications in cancer research and therapeutic development.
Me-Tet-PEG5-NHS is an ADC linker designed to facilitate site-specific conjugation through its Tetrazine moiety. This compound can engage in a selective inverse electron demand Diels-Alder (iEDDA) reaction with trans-cyclooctene (TCO) derivatives, enabling the formation of stable linkages in antibody-drug conjugates (ADCs). Its five PEG units enhance solubility and promote improved pharmacokinetics, making it suitable for targeted drug delivery applications in cancer research and therapeutic development.
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