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(-)-Menthol

Name: (-)-Menthol
Brand: Adooq Bioscience
SKU: A15621
Availability: InStock

Cat. No. A15621 CAS 2216-51-5

(-)-Menthol is a key component of peppermint oil that binds and activates transient receptor potential melastatin 8 (TRPM8), a Ca2+-permeable nonselective cation channel, to increase [Ca2+]i. Antitumor activity.

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Biological Activity

Target & Activity

Target	Activity	Value
Human Endogenous Metabolite

Cellular Effect

Cell Line	Activity	Value	Description	Reference
HEK293	EC50	10.1 μM	Agonist activity at full length recombinant human TRPM8 expressed in HEK293 cells assessed as increase in intracellular Ca2+ level pre-incubated for 5 mins by Fluo4-AM dye-based fluorescence assay	[PMID: 28740604]
HEK293	EC50	96 μM	Agonist activity at recombinant human TRPA1 expressed in HEK293 cells assessed as increase in intracellular Ca2+ level pre-incubated for 5 mins by Fluo4-AM dye-based fluorescence assay	[PMID: 28740604]

Specifications

Manufacturer	Adooq Bioscience
CAS Number	2216-51-5
Formula	C₁₀H₂₀O
Molecular Weight	156.27
SMILES	O[C@H]1[C@H](C(C)C)CC[C@@H](C)C1

Storage & Solubility

In Vitro Solubility

Reported Solubility

Solvent	Reported Solubility
DMSO	29 mg/mL (185.57 mM)
Water	15 mg/mL (95.98 mM)
Ethanol	29 mg/mL (185.57 mM)

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.