MePT-S-N-Pme is an inhibitor of SARS-CoV-2 RNA-dependent RNA polymerase (RdRp). This compound exhibits significant antiviral activity, demonstrating reduced reporter activity with an IC50 of 7 μM in HEK 293 cells. Additionally, MePT-S-N-Pme shows a mild inhibitory effect on nucleotidyltransferase activity. Given its ability to significantly inhibit SARS-CoV-2 replication in vitro, MePT-S-N-Pme is a valuable tool for antiviral research and the development of therapeutic strategies against COVID-19.
MePT-S-N-Pme is an inhibitor of SARS-CoV-2 RNA-dependent RNA polymerase (RdRp). This compound exhibits significant antiviral activity, demonstrating reduced reporter activity with an IC50 of 7 μM in HEK 293 cells. Additionally, MePT-S-N-Pme shows a mild inhibitory effect on nucleotidyltransferase activity. Given its ability to significantly inhibit SARS-CoV-2 replication in vitro, MePT-S-N-Pme is a valuable tool for antiviral research and the development of therapeutic strategies against COVID-19.
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