Metallo-β-lactamase-IN-12

Metallo-β-lactamase-IN-12 is a dual inhibitor targeting both metallo-β-lactamases (MβLs) such as NDM-1 and IMP-1, and serine β-lactamases (SβLs) including OXA-48 and KPC-2. It demonstrates potent antibacterial activity, with IC50 values of 0.64 μM, 1.32 μM, 1.01 μM, and 0.57 μM against these resistant enzymes. This compound is valuable for research applications focused on combating antibiotic resistance and understanding β-lactamase mechanisms.