Metallo-β-lactamase-IN-7

Metallo-β-lactamase-IN-7 is a specific inhibitor of VIM-type metallo-β-lactamases, demonstrating potent inhibition with IC50 values of 0.019 μM for VIM-2, 13.64 μM for VIM-1, and 0.38 μM for VIM-5. This compound enhances the antibacterial efficacy of Meropenem against Gram-negative bacterial strains, making it a valuable tool in combating antibiotic resistance in microbial research. Its application is crucial for studies focused on understanding and overcoming metallo-β-lactamase mediated resistance mechanisms.