Methoxy-X04 is a fluorescent dye that selectively targets beta-pleated sheets associated with amyloid Aβ plaques, effectively crossing the blood-brain barrier. It exhibits a strong in vitro binding affinity for amyloid beta (Aβ) fibrils, with a Ki value of 26.8 nM. This compound is particularly valuable for visualizing plaques, tangles, and cerebrovascular amyloid in postmortem Alzheimer's disease brain sections, providing robust specificity for research applications in neurodegenerative disease studies.
Methoxy-X04 is a fluorescent dye that selectively targets beta-pleated sheets associated with amyloid Aβ plaques, effectively crossing the blood-brain barrier. It exhibits a strong in vitro binding affinity for amyloid beta (Aβ) fibrils, with a Ki value of 26.8 nM. This compound is particularly valuable for visualizing plaques, tangles, and cerebrovascular amyloid in postmortem Alzheimer's disease brain sections, providing robust specificity for research applications in neurodegenerative disease studies.
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