MG-1102 is a first-in-class dual binder targeting both monomeric tau and pre-miRNA-146a. It exhibits specific inhibition of pre-miRNA-146a, with IC50 values of 0.21 mM for double-labeled and 0.36 mM for mono-labeled forms. Additionally, MG-1102 shows a binding affinity for tau monomers, characterized by a Kd of 3.21 mM as determined by surface plasmon resonance (SPR). This compound serves as a potential multi-target-directed ligand (MTDL) for research applications related to Alzheimer’s disease.
MG-1102 is a first-in-class dual binder targeting both monomeric tau and pre-miRNA-146a. It exhibits specific inhibition of pre-miRNA-146a, with IC50 values of 0.21 mM for double-labeled and 0.36 mM for mono-labeled forms. Additionally, MG-1102 shows a binding affinity for tau monomers, characterized by a Kd of 3.21 mM as determined by surface plasmon resonance (SPR). This compound serves as a potential multi-target-directed ligand (MTDL) for research applications related to Alzheimer’s disease.
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