Aberrant tau ligand 2

Catalog No.: A79356
Tau Ligand
Aberrant tau ligand 2 (Compound 4-12) selectively targets the tau protein, serving as a crucial ligand in research on tau pathology. This compound plays an essential role in the development of PROTAC degraders, specifically for the synthesis of C004019, facilitating studies on tau-related neurodegenerative diseases. Its application in the exploration of targeted protein degradation highlights its significance in advancing therapeutic strategies.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionAberrant tau ligand 2 (Compound 4-12) selectively targets the tau protein, serving as a crucial ligand in research on tau pathology. This compound plays an essential role in the development of PROTAC degraders, specifically for the synthesis of C004019, facilitating studies on tau-related neurodegenerative diseases. Its application in the exploration of targeted protein degradation highlights its significance in advancing therapeutic strategies.
Product Information
Catalog NumA79356
FormulaC19H27N7O3S
Molecular Weight433.53
CAS Number2417159-58-9
SMILESO=C(O)CN(C1=NC(N2CCN(C(C)=O)CCC2)=NC(NCCC3=CC=CS3)=N1)C
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