Milameline hydrochloride is a nonselective, partial agonist of muscarinic receptors, demonstrated to enhance cognitive function. It exhibits comparable affinity across various human muscarinic receptor subtypes, with IC50 values of 1.3 µM for M1, 1.1 µM for M2, 1.5 µM for M3, and 1.9 µM for M4 receptors. Milameline hydrochloride produces both central and peripheral cholinergic effects and effectively reverses cognitive deficits induced by scopolamine. This compound serves as a valuable tool for research related to Alzheimer's disease and cognitive impairment.
Milameline hydrochloride is a nonselective, partial agonist of muscarinic receptors, demonstrated to enhance cognitive function. It exhibits comparable affinity across various human muscarinic receptor subtypes, with IC50 values of 1.3 µM for M1, 1.1 µM for M2, 1.5 µM for M3, and 1.9 µM for M4 receptors. Milameline hydrochloride produces both central and peripheral cholinergic effects and effectively reverses cognitive deficits induced by scopolamine. This compound serves as a valuable tool for research related to Alzheimer's disease and cognitive impairment.
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