Fig. 1 · Structure
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Milameline
Muscarinic Receptor Agonist
Milameline is a nonselective, partial agonist of muscarinic receptors, demonstrating significant potential in cognitive enhancement. It exhibits balanced affinity across various human muscarinic receptor subtypes, with IC50 values of approximately 1.3 µM for M1, 1.1 µM for M2, 1.5 µM for M3, and 1.9 µM for M4 receptors. In addition to its central and peripheral cholinergic effects, Milameline counteracts cognitive deficits induced by Scopolamine. This compound is valuable for researching Alzheimer's Disease and other cognitive disorders.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Partial Agonist |
| CAS Number | 139886-32-1 |
| Applications | Muscarinic Receptor Agonist |
| Formula | C8H14N2O |
| Molecular Weight | 154.21 |
| Synonyms | CI-979; RU35926 |
| SMILES | CO/N=C/C1=CCCN(C)C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.