Mitotane-13C6 is a stable isotope-labeled form of Mitotane (2,4′-DDD), which targets adrenocortical carcinoma. This antineoplastic agent exerts its effects primarily through lipotoxicity resulting from the accumulation of intracellular free cholesterol. Additionally, Mitotane influences pituitary function by affecting corticotroph cells and induces CYP3A4 gene expression via activation of the steroid and xenobiotic receptor (SXR). This compound is essential for studies investigating adrenocortical function and drug interactions.
Mitotane-13C6 is a stable isotope-labeled form of Mitotane (2,4′-DDD), which targets adrenocortical carcinoma. This antineoplastic agent exerts its effects primarily through lipotoxicity resulting from the accumulation of intracellular free cholesterol. Additionally, Mitotane influences pituitary function by affecting corticotroph cells and induces CYP3A4 gene expression via activation of the steroid and xenobiotic receptor (SXR). This compound is essential for studies investigating adrenocortical function and drug interactions.
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