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MK-7762

Antitubercular Agent

MK-7762 is an orally active xazolidinone compound that functions as an antitubercular agent. Its primary mechanism involves the inhibition of MAO-B and mammalian mitochondrial protein synthesis, leading to a reduction in bacterial load. In preclinical models, MK-7762 demonstrates efficacy by decreasing lung bacterial burden in BALB/c mice with both acute and chronic tuberculosis, as well as effectively penetrating caseous necrotic lung lesions in C3HeB/FeJ mice. This compound is valuable for research focused on tuberculosis management and treatment strategies.

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Specifications

Manufacturer	Adooq Bioscience
CAS Number	2706576-88-5
Applications	Antitubercular Agent
Formula	C₁₆H₁₉F₂N₃O₆S
Molecular Weight	419.40
Synonyms	TBD09
SMILES	COC(NC[C@H]1CN(C(O1)=O)C2=CC(F)=C(C(F)=C2)N3CCS(=O)(CC3)=O)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.