ML221

Catalog No.: A19446

APJ functional antagonist

ML221

ML221 Chemical Structure

CAS NO. 877636-42-5

ML221 is a potent apelin (APJ) functional antagonist, inhibiting apelin-13-mediated activation of APJ, with IC50s of 0.70 μM in the cAMP assay, and 1.75 μM in the β-arrestin assay, and EC80 of 10 nM in both assays.

Availability: In stock

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5 mg

Regular Price: $65.00

Special Price $52.00

10 mg

Regular Price: $110.00

Special Price $88.00

50 mg

Regular Price: $330.00

Special Price $264.00

100 mg

Regular Price: $560.00

Special Price $448.00

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Biological Activity

ML221 is a potent apelin (APJ) functional antagonist, inhibiting apelin-13-mediated activation of APJ, with IC50s of 0.70 μM in the cAMP assay, and 1.75 μM in the β-arrestin assay, and EC80 of 10 nM in both assays.
In vitro DMSO 8 mg/mL (20.76 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 25.95 mL 129.75 mL 259.5 mL
0.5 mM 5.19 mL 25.95 mL 51.9 mL
1 mM 2.6 mL 12.98 mL 25.95 mL
5 mM 0.52 mL 2.6 mL 5.19 mL

*The above data is based on the productmolecular weight 385.35. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A19446
Actions Antagonist
CAS No. 877636-42-5
Formula C17H11N3O6S
M. Wt 385.35
Purity >98%
Synonyms ML 221, ML-221
SMILES O=C1C=C(CSC2=NC=CC=N2)OC=C1OC(C3=CC=C([N+]([O-])=O)C=C3)=O
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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