Fig. 1 · Structure
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MMP408
MMP Inhibitor
MMP408 is a selective inhibitor of matrix metalloproteinase-12 (MMP-12), exhibiting potent activity with IC50 values of 2 nM, 160 nM, and 3 μM for human, mouse, and rat MMP-12, respectively. It also demonstrates an IC50 value of 120 nM against human MMP-13, while showing limited activity against other matrix metalloproteinases. MMP408 has potential applications in researching inflammation, fibrosis, and tissue remodeling, particularly in the context of chronic obstructive pulmonary disease and chronic sinusitis with nasal polyps.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1025716-81-7 |
| Applications | MMP Inhibitor |
| Formula | C19H20N2O7S |
| Molecular Weight | 420.44 |
| SMILES | CC(C)[C@@H](C(O)=O)NS(=O)(C1=CC=C2C(OC3=CC=C(NC(OC)=O)C=C23)=C1)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.