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MsbA-IN-5

MsbA Inhibitor

MsbA-IN-5 is a selective inhibitor of the MsbA transport protein, exhibiting an IC50 value of 2 nM. This compound demonstrates significant antibacterial activity against Gram-negative bacteria, including Escherichia coli and Klebsiella pneumoniae, with minimum inhibitory concentrations (MICs) of 12 μM and 25 μM, respectively. MsbA-IN-5 serves as a valuable tool for research aimed at elucidating the mechanisms of resistance in Gram-negative pathogens and developing new antimicrobial strategies.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	2909443-06-5
Applications	MsbA Inhibitor
Formula	C₂₃H₁₉Cl₂N₅O
Molecular Weight	452.34
SMILES	C[C@@H](C1=C(Cl)C=CC=C1Cl)OC2=CC=C3N=CC(/C=C/C4=NNN=N4)=C(C5CC5)C3=C2

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.