Fig. 1 · Structure
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MsbA-IN-6
MsbA Inhibitor
MsbA-IN-6 is a potent inhibitor targeting the ATP-binding cassette (ABC) transporter MsbA, crucial for the transport of lipopolysaccharide in Gram-negative bacteria. This compound exhibits significant antibacterial activity against Escherichia coli by effectively inhibiting MsbA's ATPase and transport functions. MsbA-IN-6 retains efficacy against clinical multidrug-resistant strains, making it a valuable tool for research on antibiotic resistance and transporter dynamics.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2909443-13-4 |
| Applications | MsbA Inhibitor |
| Formula | C24H20Cl2N4O |
| Molecular Weight | 451.35 |
| SMILES | C[C@H](OC1=CC2=C(C(/C=C/C3=NNN=N3)=CC=C2C=C1)C4CC4)C5=C(C=CC=C5Cl)Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.