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Biological Activity
MSC1094308 is a reversible and allosteric inhibitor of the type II AAA ATPase human ubiquitin-directed unfoldase (VCP)/p97 and the type I AAA ATPase VPS4B, with IC50 values of 0.71 μM and 7.2 μM for VPS4B and p97, respectively.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 21.62 mL | 108.1 mL | 216.19 mL |
| 0.5 mM | 4.32 mL | 21.62 mL | 43.24 mL |
| 1 mM | 2.16 mL | 10.81 mL | 21.62 mL |
| 5 mM | 0.43 mL | 2.16 mL | 4.32 mL |
*The above data is based on the productmolecular weight 462.55. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A19120 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 2219320-08-6 |
| Formula | C29H29F3N2 |
| M. Wt | 462.55 |
| Purity | >98% |
| Synonyms | MSC-1094308; MSC 1094308 |
| SMILES | FC1=CC=C(C(C2=CC=C(F)C=C2)CCCNCC3CCC(NC4=C5C=C(F)C=C4)=C5C3)C=C1 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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