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MtTMPK-IN-1

MtTMPK Inhibitor

MtTMPK-IN-1 is a selective inhibitor of Mycobacterium tuberculosis thymidylate kinase (MtTMPK), demonstrating a potent inhibitory effect with an IC50 value of 2.5 μM. This compound exhibits moderate to weak anti-tubercular activity against the Mtb H37Rv strain while maintaining low cytotoxicity in human fibroblast cells (MRC-5). MtTMPK-IN-1 serves as a valuable tool for tuberculosis research, aiding in the exploration of therapeutic strategies targeting MtTMPK.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	2799607-58-0
Applications	MtTMPK Inhibitor
Formula	C₂₂H₂₄N₄O₃
Molecular Weight	392.45
SMILES	CC1=CN(C(NC1=O)=O)C2CCN(CC2)CC3=NC(OC4=CC=CC=C4)=CC=C3

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.