Fig. 1 · Structure

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MtTMPK-IN-9

MtbTMPK Inhibitor

MtTMPK-IN-9 is a selective inhibitor of Mycobacterium tuberculosis thymidylate kinase (MtbTMPK) with an IC50 value of 48 μM. This compound exhibits sub-micromolar antibacterial activity against mycobacterial strains, with minimum inhibitory concentrations (MICs) ranging from 6.25 to 9.4 μM, while demonstrating low cytotoxicity in mammalian cells. MtTMPK-IN-9 is a valuable tool for research into tuberculosis and the development of new therapeutic strategies targeting MtbTMPK.

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Specifications

Manufacturer Adooq Bioscience
Actions Inhibitor
CAS Number 2987299-68-1
Applications MtbTMPK Inhibitor
Formula C25H26N6O7
Molecular Weight 522.51
SMILES
CC1=CN(C(NC1=O)=O)C2CCN(CC2)CC3=CC=C(C=C3)CNC(C4=CC([N+]([O-])=O)=CC([N+]([O-])=O)=C4)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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