N-(4-acetamidophenyl)-indomethacin amide is a selective reversible inhibitor of cyclooxygenase-2 (COX-2). It demonstrates potent inhibitory activity against human recombinant and ovine COX-2, with IC50 values of 0.12 μM and 0.625 μM, respectively, while showing significantly lower potency against COX-1 isoforms. This compound is valuable for research applications focused on inflammation, pain management, and the role of COX-2 in various pathological conditions.
N-(4-acetamidophenyl)-indomethacin amide is a selective reversible inhibitor of cyclooxygenase-2 (COX-2). It demonstrates potent inhibitory activity against human recombinant and ovine COX-2, with IC50 values of 0.12 μM and 0.625 μM, respectively, while showing significantly lower potency against COX-1 isoforms. This compound is valuable for research applications focused on inflammation, pain management, and the role of COX-2 in various pathological conditions.
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