N-Desethyl Sunitinib-d5 hydrochloride

Catalog No.: A70745
Stable Isotope
N-Desethyl Sunitinib-d5 hydrochloride is a deuterated analog of N-Desethyl Sunitinib, a significant metabolite of the multi-targeted kinase inhibitor, sunitinib. This compound functions primarily as a stable isotope for quantitative analysis in pharmacokinetic studies. It demonstrates potent inhibition of vascular endothelial growth factor receptors (VEGFR) as well as platelet-derived growth factor receptor beta (PDGFRβ) and KIT, making it useful in research involving angiogenesis and tumor progression.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionN-Desethyl Sunitinib-d5 hydrochloride is a deuterated analog of N-Desethyl Sunitinib, a significant metabolite of the multi-targeted kinase inhibitor, sunitinib. This compound functions primarily as a stable isotope for quantitative analysis in pharmacokinetic studies. It demonstrates potent inhibition of vascular endothelial growth factor receptors (VEGFR) as well as platelet-derived growth factor receptor beta (PDGFRβ) and KIT, making it useful in research involving angiogenesis and tumor progression.
Product Information
Catalog NumA70745
FormulaC20H19D5ClFN4O2
Molecular Weight411.91
CAS Number1261432-14-7
SMILESO=C(/C(C1=C2)=C/C3=C(C(C(NCCNC([2H])([2H])C([2H])([2H])[2H])=O)=C(N3)C)C)NC1=CC=C2F.Cl
SynonymsSU-12662-d5 hydrochloride
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