N-(Iodoacetamido)-Doxorubicin

Catalog No.: A43089
ADC Linker
N-(Iodoacetamido)-Doxorubicin is a cleavable linker designed for the synthesis of antibody-drug conjugates (ADCs). This reagent enables the targeted delivery of doxorubicin, a potent chemotherapeutic agent, by covalently binding to antibodies, thereby enhancing the therapeutic efficacy and specificity of the conjugate. Its unique bioconjugation properties make it a valuable tool in cancer research, particularly in the development of innovative ADC therapies.
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5mg
10mg
50mg
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Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionN-(Iodoacetamido)-Doxorubicin is a cleavable linker designed for the synthesis of antibody-drug conjugates (ADCs). This reagent enables the targeted delivery of doxorubicin, a potent chemotherapeutic agent, by covalently binding to antibodies, thereby enhancing the therapeutic efficacy and specificity of the conjugate. Its unique bioconjugation properties make it a valuable tool in cancer research, particularly in the development of innovative ADC therapies.
Product Information
Catalog NumA43089
FormulaC29H30INO12
Molecular Weight711.45
CAS Number114390-30-6
SMILESCOC1=CC=CC2=C1C(C3=C(C2=O)C(O)=C4C([C@@H](O[C@@H]5O[C@@H](C)[C@@H](O)[C@@H](NC(CI)=O)C5)C[C@@](C(CO)=O)(O)C4)=C3O)=O
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