Fig. 1 · Structure
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N1,N11-Diethylnorspermine hydrobromide
Anticancer Agent
N1,N11-Diethylnorspermine hydrobromide is a novel anticancer agent that targets polyamine metabolism. As a spermine analog, it stimulates polyamine catabolism and promotes the release of cytochrome c from mitochondria, leading to the activation of caspase 3. This compound effectively induces cell death in glioblastoma multiforme (GBM) cells by enhancing SSAT (spermidine/spermine N1-acetyltransferase) activity, which is associated with increased hydrogen peroxide production. Its application in cancer research offers insights into therapeutic strategies against aggressive tumors.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 1384898-58-1 |
| Applications | Anticancer Agent |
| Formula | C13H36Br4N4 |
| Molecular Weight | 568.07 |
| SMILES | CCNCCCNCCCNCCCNCC.Br.Br.Br.Br |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.