N1,N11-Diethylnorspermine tetrahydrochloride is a potent anticancer agent that primarily targets polyamine metabolism. It activates polyamine catabolism and downregulates mTOR signaling pathways, leading to the induction of SSAT and production of hydrogen peroxide. Through the release of cytochrome c from mitochondria, it effectively activates caspase 3, promoting apoptosis in glioblastoma multiforme (GBM) cells. This reagent is valuable for research focused on cancer biology and therapies targeting polyamine synthesis and metabolism.
N1,N11-Diethylnorspermine tetrahydrochloride is a potent anticancer agent that primarily targets polyamine metabolism. It activates polyamine catabolism and downregulates mTOR signaling pathways, leading to the induction of SSAT and production of hydrogen peroxide. Through the release of cytochrome c from mitochondria, it effectively activates caspase 3, promoting apoptosis in glioblastoma multiforme (GBM) cells. This reagent is valuable for research focused on cancer biology and therapies targeting polyamine synthesis and metabolism.
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