NA-Ir is a potent ferroptosis inducer that targets mitochondrial DNA (mtDNA) and activates the cGAS-STING signaling pathway, promoting ferritinophagy. It generates reactive oxygen species (ROS) through photodynamic therapy (PDT) while depleting glutathione (GSH) and downregulating glutathione peroxidase 4 (GPX4), leading to lipid peroxidation and the initiation of ferroptosis. NA-Ir demonstrates increased anticancer efficacy when exposed to light, selectively impairing cancer cells characterized by elevated levels of hydrogen sulfide (H2S).
NA-Ir is a potent ferroptosis inducer that targets mitochondrial DNA (mtDNA) and activates the cGAS-STING signaling pathway, promoting ferritinophagy. It generates reactive oxygen species (ROS) through photodynamic therapy (PDT) while depleting glutathione (GSH) and downregulating glutathione peroxidase 4 (GPX4), leading to lipid peroxidation and the initiation of ferroptosis. NA-Ir demonstrates increased anticancer efficacy when exposed to light, selectively impairing cancer cells characterized by elevated levels of hydrogen sulfide (H2S).
This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:
