NC-III-49-1 is a potent bivalent bromodomain and extraterminal domain (BET) inhibitor with high affinity for BRD4 and BRDT family proteins, exhibiting Kd values of 0.095 nM for BRD4-1, 0.32 nM for BRD4-2, and 5.5 nM for BRDT-2, among others. This compound demonstrates notable antiproliferative activity and effectively reduces c-Myc expression. NC-III-49-1 is valuable for research in cancer biology and therapeutic studies targeting BET-related pathways.
NC-III-49-1 is a potent bivalent bromodomain and extraterminal domain (BET) inhibitor with high affinity for BRD4 and BRDT family proteins, exhibiting Kd values of 0.095 nM for BRD4-1, 0.32 nM for BRD4-2, and 5.5 nM for BRDT-2, among others. This compound demonstrates notable antiproliferative activity and effectively reduces c-Myc expression. NC-III-49-1 is valuable for research in cancer biology and therapeutic studies targeting BET-related pathways.
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