Neoaureothin is a bacterial metabolite derived from Streptomyces that functions as an androgen receptor (AR) antagonist. It effectively inhibits the binding of dihydrotestosterone (DHT) to ARs, demonstrating an IC50 of 13 μM, and significantly reduces DHT-induced prostate-specific antigen expression in LNCaP cells with an IC50 of 1.75 nM. Additionally, Neoaureothin exhibits cytotoxic effects on A549, HCT116, and HepG2 cell lines with IC50 values of 34.3, 47, and 37.2 μg/mL, respectively. It also displays potent nematocidal activity against B. xylophilus, with an LC50 of 0.84 μg/mL, and enhances the survival of P. densiflora trees infected with this nematode.
Neoaureothin is a bacterial metabolite derived from Streptomyces that functions as an androgen receptor (AR) antagonist. It effectively inhibits the binding of dihydrotestosterone (DHT) to ARs, demonstrating an IC50 of 13 μM, and significantly reduces DHT-induced prostate-specific antigen expression in LNCaP cells with an IC50 of 1.75 nM. Additionally, Neoaureothin exhibits cytotoxic effects on A549, HCT116, and HepG2 cell lines with IC50 values of 34.3, 47, and 37.2 μg/mL, respectively. It also displays potent nematocidal activity against B. xylophilus, with an LC50 of 0.84 μg/mL, and enhances the survival of P. densiflora trees infected with this nematode.
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