- Cat. No.
- A21016
ARN2966
ARN2966 is a potent post-transcriptional modulator of APP expression; reduces expression of APP with resultant lower production of Aβ.
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- Cat. No.
- A37248
Aβ42-IN-2
Aβ42-IN-2 is a potent γ-secretase modulator, specifically targeting Aβ42 with an IC50 of 6.5 nM. This compound is essential for studying the modulation of amyloid beta peptide levels, making it a valuable tool for Alzheimer's disease research. Its selective inhibition of Aβ42 provides insights into the mechanisms underlying amyloid pathology and potential therapeutic strategies.
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- Cat. No.
- A67082
Simufilam hydrochloride
Synonyms: PTI-125 hydrochloride
Simufilam hydrochloride is an orally active modulator of filamin A (FLNA) that targets neuronal signaling pathways. This compound restores NMDAR signaling and Arc expression while inhibiting dysregulated mTOR activity. Additionally, it enhances insulin sensitivity and mitigates Aβ42-induced neuroinflammation and tau protein hyperphosphorylation. Simufilam hydrochloride is applicable in research related to Alzheimer's disease, particularly in understanding the underlying mechanisms of neurodegeneration.
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- Cat. No.
- A67113
Simufilam
Synonyms: PTI-125
Simufilam is an orally active modulator of filamin A (FLNA) that restores NMDA receptor (NMDAR) signaling and Arc expression. It effectively inhibits overactive mTOR signaling by restoring the normal conformation of FLNA, which results in improved insulin sensitivity and a reduction in Aβ42-induced neuroinflammation and tau protein hyperphosphorylation. This compound is particularly valuable for research applications focused on Alzheimer's disease and related neurodegenerative disorders.
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- Cat. No.
- A78290
LC kinetic stabilizer-2
LC Kinetic Stabilizer-2 is a potent agent designed to stabilize amyloidogenic immunoglobulin light chains (LC) by enhancing their kinetic stability, with an EC50 of 24 nM. This compound is particularly useful in research applications focused on protein misfolding diseases, amyloidosis, and related pathologies. It enables the investigation of LC dynamics and potential therapeutic interventions to prevent aggregation in affected tissues.
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- Cat. No.
- A78416
γ-Secretase modulator 13
γ-Secretase modulator 13 is a gamma-secretase modulator that inhibits the production of the aggregated amyloid β-peptide Aβ42, exhibiting an IC50 value of 163 nM. This compound is valuable for research in Alzheimer's disease, facilitating investigations into amyloidogenic processes and potential therapeutic interventions. Its specific modulation of γ-secretase activity positions it as a significant tool for studying the mechanisms underlying neurodegenerative disorders.
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- Cat. No.
- A78420
gamma-secretase modulator 5
Gamma-secretase modulator 5 is a selective gamma-secretase modulator that effectively inhibits the production of the aggregated amyloid β-peptide Aβ42 with an IC50 value of 60 nM. This compound demonstrates the ability to penetrate the blood-brain barrier, making it a valuable tool in the investigation of Alzheimer's disease mechanisms. It is suitable for research applications aimed at understanding the role of gamma-secretase in neurodegenerative disorders.
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- Cat. No.
- A78459
APP modulator-1
APP Modulator-1 is a compound that specifically targets the amyloid precursor protein (APP) to influence its processing and thereby modulate the production of amyloid-beta peptides. This activity suggests potential applications in Alzheimer's disease research, particularly in understanding the mechanisms of amyloid plaque formation. APP Modulator-1 is suitable for studies aimed at elucidating the role of APP in neurodegenerative disorders and developing therapeutic strategies for related conditions.
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