Search by product name, CAS, target or catalog number. Press Down Arrow to reach product suggestions, Tab to move between links, and Escape to close suggestions.
Dopamine transporter (DAT) inhibitors and probes act on the carrier that clears released dopamine. DAT was cloned as a cocaine-sensitive transporter, and mice lacking it show hyperlocomotion and no behavioral response to cocaine or amphetamine. The X-ray structure of the Drosophila transporter bound to an antidepressant revealed its central binding site. Listed compounds include LR1143 and SRI-32743, radafaxine hydrochloride, which inhibits dopamine and norepinephrine uptake, and DOV-102,677, which also blocks serotonin transport. IDT307 is a fluorescent transporter substrate used to measure monoamine uptake in cells.
SRI-32743 is an allosteric modulator of the human dopamine transporter (hDAT) with an IC50 value of 9.86 μM. This compound is of particular interest for research into HIV-Tat-induced neurotoxicity. Its modulation of hDAT may provide insights into the neurobiological mechanisms underlying dopamine dysregulation in various neurotoxic conditions.
Out of stock
All 3 sizes
SRI-29574 is an allosteric modulator of the dopamine transporter (DAT), exhibiting a partial inhibitory effect on DAT uptake with an IC50 of 2.3 nM. Additionally, it demonstrates partial inhibition of the serotonin transporter (SERT) and norepinephrine transporter (NET). This compound is a valuable tool for investigating the function and regulatory processes associated with DAT, contributing to research in neuropharmacology and the study of mood and anxiety disorders.
Out of stock
All 3 sizes