Tau Protein

Cat. No.

A67082

CAS No.

2480226-07-9

Simufilam hydrochloride

Synonyms: PTI-125 hydrochloride

Simufilam hydrochloride is an orally active modulator of filamin A (FLNA) that targets neuronal signaling pathways. This compound restores NMDAR signaling and Arc expression while inhibiting dysregulated mTOR activity. Additionally, it enhances insulin sensitivity and mitigates Aβ42-induced neuroinflammation and tau protein hyperphosphorylation. Simufilam hydrochloride is applicable in research related to Alzheimer's disease, particularly in understanding the underlying mechanisms of neurodegeneration.

Cat. No.

A67113

CAS No.

1224591-33-6

Simufilam

Synonyms: PTI-125

Simufilam is an orally active modulator of filamin A (FLNA) that restores NMDA receptor (NMDAR) signaling and Arc expression. It effectively inhibits overactive mTOR signaling by restoring the normal conformation of FLNA, which results in improved insulin sensitivity and a reduction in Aβ42-induced neuroinflammation and tau protein hyperphosphorylation. This compound is particularly valuable for research applications focused on Alzheimer's disease and related neurodegenerative disorders.

Cat. No.

A79349

CAS No.

2476726-76-6

PTC-700

PTC-700 is a potent modulator of microtubule-associated protein tau (MAPT) splicing. This compound effectively reduces 4-repeat isoform MAPT levels in P301L and S305N neuronal models, exhibiting EC50 values of 1.3-1.8 nM and 0.5-2.6 nM, respectively. PTC-700 is utilized in research applications focused on tauopathies and neurodegenerative disorders, contributing to the understanding of tau protein dynamics and potential therapeutic avenues.