Fig. 1 · Structure
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Nilofabicin
FabI Inhibitor
Nilofabicin is a potent inhibitor of the enoyl-(acyl-carrier protein) reductase (FabI), a vital enzyme in fatty acid synthesis. It demonstrates bactericidal activity with a minimum inhibitory concentration (MIC90) of 0.5 µg/ml against Staphylococcus aureus strains, surpassing the efficacy of linezolid and vancomycin. This compound is suitable for research applications focused on antimicrobial drug development and resistance mechanisms.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 934628-27-0 |
| Applications | FabI Inhibitor |
| Formula | C19H20N2O2S |
| Molecular Weight | 340.44 |
| Synonyms | CG-400549 |
| SMILES | O=C1C=C(OCCC2=CC=CS2)C=CN1CC3=CC=CC(N)=C3C |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.