Nipamovir is a nitroimidazole prodrug that serves as an anti-HIV agent. It demonstrates significant antiviral activity in both cellular assays and a human ex vivo model of HIV infection, showing comparable efficacy to other reference compounds while maintaining low toxicity. Nipamovir exhibits EC50 values of 3.64±3.28 μM for CEM-SS/HIV-1RF and 3.23±2.81 μM for hPBMC/HIV-192HT599, highlighting its potential in HIV research applications.
Nipamovir is a nitroimidazole prodrug that serves as an anti-HIV agent. It demonstrates significant antiviral activity in both cellular assays and a human ex vivo model of HIV infection, showing comparable efficacy to other reference compounds while maintaining low toxicity. Nipamovir exhibits EC50 values of 3.64±3.28 μM for CEM-SS/HIV-1RF and 3.23±2.81 μM for hPBMC/HIV-192HT599, highlighting its potential in HIV research applications.
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