Fig. 1 · Structure
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NITD-916
InhA Inhibitor
NITD-916 is an orally active inhibitor of the mycobacterial enoyl reductase InhA, exhibiting an IC50 of 570 nM. It forms a ternary complex with InhA and NADH, efficiently obstructing the access to the fatty acyl substrate binding pocket. By inhibiting InhA, NITD-916 disrupts mycolic acid synthesis, leading to cell death in mycobacterial species. This compound demonstrates significant anti-tuberculosis activity, making it a valuable tool for research into tuberculosis treatment and mycobacterial biology.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1614262-83-7 |
| Applications | InhA Inhibitor |
| Formula | C20H25NO2 |
| Molecular Weight | 311.42 |
| SMILES | O=C1C(C2=CC=CC=C2)=C(O)C=C(CC3CCC(C)(C)CC3)N1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.