Fig. 1 · Structure
Documents & Downloads
NSC-60339
Efflux Pump Inhibitor
NSC-60339 is an efflux pump inhibitor identified as a substrate of the AcrAB-TolC system. This polybasic terephthalic acid derivative demonstrates significant potential in enhancing the efficacy of cancer chemotherapeutic agents by overcoming drug resistance mechanisms. Its role as a research tool can facilitate the investigation of multidrug resistance pathways in cancer cells.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 70-09-7 |
| Applications | Efflux Pump Inhibitor |
| Formula | C26H23ClN6O2 |
| Molecular Weight | 486.95 |
| SMILES | O=C(C1=CC=C(C=C1Cl)C(NC2=CC=C(C=C2)C3=NCCN3)=O)NC4=CC=C(C=C4)C5=NCCN5 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.