OR-1855 is an active metabolite of Levosimendan that primarily targets myometrial contractility. It demonstrates anti-inflammatory properties by inhibiting IL-1β-induced reactive oxygen species (ROS) formation and NAD(P)H oxidase-dependent superoxide radical generation in human umbilical vein endothelial cells (HUVECs). Furthermore, OR-1855 suppresses IL-1β-induced phosphorylation of key signaling molecules, including p38 MAPK, ERK1/2, c-Jun, and JNK. This compound is valuable for research focused on inflammation and related biological processes.
OR-1855 is an active metabolite of Levosimendan that primarily targets myometrial contractility. It demonstrates anti-inflammatory properties by inhibiting IL-1β-induced reactive oxygen species (ROS) formation and NAD(P)H oxidase-dependent superoxide radical generation in human umbilical vein endothelial cells (HUVECs). Furthermore, OR-1855 suppresses IL-1β-induced phosphorylation of key signaling molecules, including p38 MAPK, ERK1/2, c-Jun, and JNK. This compound is valuable for research focused on inflammation and related biological processes.
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