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Other Inhibitors groups bioactive small molecules whose targets fall outside the pathway categories of this catalogue. The compounds have not yet been assigned to target categories, so the range is broad and uneven. Streptozotocin, a glucosamine-nitrosourea compound used to induce experimental diabetes in rodents, sits beside the O-GlcNAcase inhibitor Thiamet G. Exherin is an N-cadherin antagonist, and AdipoRon is an agonist of adiponectin receptors 1 and 2 (AdipoR1 and AdipoR2). Plant compounds such as the isoflavone daidzein are also included. Despite the category name, not every compound is an inhibitor, as the AdipoRon example shows. Compounds with a well-defined target are usually listed in the matching pathway or target category.
Synonyms: Org-9426
Rocuronium (Org-9426) is an aminosteroid non-depolarizing neuromuscular blocker or muscle relaxant used in modern anaesthesia.
CPI-268456 is a ligand of bromodomain-containing protein 4 (BRD4). It binds to BRD4 (IC50 =
Synonyms: J2.865.885K
DPA-714 is a selective ligand for the translocator protein (TSPO) currently under evaluation for several clinical applications.It is also a PET tracer binding the TSPO receptor and highly expressed in myeloid cells.
DMT1 blocker 1 is a blocker of divalent metal transporter 1 (DMT1) with an IC50 of 0.64 μM, is expected to block iron uptake by enterocytes in vivo.
Octaaminocryptand 1 is an aminocryptand ligand.
BTTAA is a Cu(I)-stabilizing ligand, whch performs potently with ubiquitin Glu18AzF.
