Drug Derivative

Drug derivatives are analogs, stereoisomers, esters and conjugates based on known drugs or natural products. C5 Lenalidomide is a variant of lenalidomide, a ligand of the E3 ubiquitin ligase substrate receptor cereblon. The stereoisomers (1R,9S)-Exatecan and (9R)-Exatecan relate to exatecan, a camptothecin-derived topoisomerase I inhibitor. rel-Latanoprost acid corresponds to the free acid of latanoprost, a prostaglandin F2α analog, with relative stereochemistry. Natural product esters are also included, such as cycloartenyl ferulate, an ester of ferulic acid with the triterpenoid alcohol cycloartenol. These compounds support structure-activity studies, comparisons between stereoisomers and the design of conjugates. Precursors used earlier in a synthesis route are listed under Drug Intermediate.

7 Items

  • rel-Latanoprost acid
    Cat. No.
    A25665

    rel-Latanoprost acid

    rel-Latanoprost acid is a relative configuration of Latanoprost acid. Latanoprost acid, an analog of prostaglandin (PG) F2α, is an selective prostanoid receptor (FP) agonist that specifically activates the FP-PG receptor. Latanoprost acid inhibits RANKL-induced osteoclastgenesis and function by inhibiting ERK, AKT, JNK, and p38 cascade, following by the c-fos/NFATc1 pathway. Latanoprost acid is a medication which works to lower pressure inside the eyes.

    Out of stock

    All 3 sizes
  • 8(R)-Hydroxyoctadecanoic acid
    Cat. No.
    A93170

    8(R)-Hydroxyoctadecanoic acid

    8(R)-Hydroxyoctadecanoic acid is an ester product known for its role in lipid metabolism. This compound exhibits biological activity as an activator of peroxisome proliferator-activated receptors (PPARs), which are involved in the regulation of fatty acid storage and glucose metabolism. It can be utilized in research applications focused on metabolic disorders, inflammation, and cardiovascular diseases, providing insights into the physiological roles of fatty acids in cellular processes.

    Out of stock

    All 3 sizes
  • 5-HT4R agonist-1
    Cat. No.
    A95641

    5-HT4R agonist-1

    5-HT4R agonist-1 is a selective agonist for the 5-hydroxytryptamine 4 receptor (5-HT4R), a target involved in various neuropharmacological processes. This compound exhibits significant biological activity in modulating gastrointestinal motility and cognitive functions. It serves as a valuable tool in research applications focused on gastrointestinal disorders and neurodegenerative diseases, aiding in the exploration of therapeutic strategies targeting the serotonergic system.

    25 mg
    $1,405.00
    50 mg
    $1,790.00
    All 3 sizes
  • STING agonist-49-CO-C2-mal-Cys
    Cat. No.
    A96372

    STING agonist-49-CO-C2-mal-Cys

    STING agonist-49-CO-C2-mal-Cys is a derivative of the STING agonist designed to facilitate the catabolism of antibody-drug conjugates (ADCs) and promote payload release. This compound exhibits significant antitumor activity in vivo, making it a valuable tool in cancer research. Its unique structure provides essential interactions with target proteins and E3 ligases, contributing to its efficacy in therapeutic applications.

    Out of stock

    All 3 sizes
  • RU 24926
    Cat. No.
    A96413

    RU 24926

    RU 24926 is a drug derivative that functions primarily as a selective agonist for the corticotropin-releasing hormone receptor 1 (CRHR1). This compound exhibits key biological activity in modulating stress responses and has been utilized in research related to anxiety and depression models. RU 24926 serves as an important tool for investigating the pathways involved in neuroendocrine regulation and stress-related disorders.

    25 mg
    $1,275.00
    50 mg
    $1,625.00
    All 3 sizes
  • MNI-D-aspartate
    Cat. No.
    A96515

    MNI-D-aspartate

    MNI-D-aspartate is a potent drug derivative that acts as an NMDA receptor agonist. It plays a critical role in neurotransmission and is vital for studies related to excitatory signaling in the central nervous system. Research applications include investigations into neuropharmacology and the modulation of synaptic plasticity, making it valuable for understanding various neurological conditions.

    10 mg
    $355.00
    50 mg
    $1,455.00
    All 2 sizes
  • β-Methoxy 2C-D hydrochloride
    Cat. No.
    A97088

    β-Methoxy 2C-D hydrochloride

    β-Methoxy 2C-D hydrochloride is a phenethylamine derivative that functions primarily as a selective serotonin receptor agonist. This compound exhibits psychoactive properties and has potential applications in neuroscience research, particularly in the study of serotonin modulation and its effects on behavior. β-Methoxy 2C-D hydrochloride serves as a valuable tool for investigating the pharmacological profiles of serotonin receptor activity and related signaling pathways.

    1 mg
    $165.00
    5 mg
    $500.00
    All 2 sizes

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