Drug Intermediate

Drug intermediates are building blocks and reagents used to synthesize active compounds and their analogs. The category covers small aromatic ketones and acids, aliphatic keto acids, sugars and amino acid-related compounds. 2'-Hydroxyacetophenone, an ortho-substituted aromatic ketone, is a common precursor of chromones and flavonoids. Phenylglyoxylic acid carries an α-keto acid group on a benzene ring, while levulinic acid is a biomass-derived keto acid used as a platform chemical. Carbohydrate intermediates include DL-Xylose and N-acetyl-D-mannosamine, a biosynthetic precursor of sialic acids. Several entries are also endogenous metabolites or salts, so they serve biochemical as well as synthetic work. Compounds built by modifying an existing drug structure are listed under Drug Derivative.

5 Items

  • 2-Amino-6-bromopyridine
    Cat. No.
    A48259

    2-Amino-6-bromopyridine

    2-Amino-6-bromopyridine acts as a PqsR ligand, exhibiting a dissociation constant (Kd) of 6.8 μM as determined by surface plasmon resonance (SPR) assays. This compound demonstrates weak antagonistic activity and serves as an intermediate in the synthesis of JAK2 and MSK1 inhibitors. Furthermore, 2-Amino-6-bromopyridine is useful in research focused on Pseudomonas aeruginosa infections, contributing to studies aimed at understanding bacterial communication and virulence factors.

    1 g
    $20.00
    5 g
    $25.00
    All 6 sizes
  • 4,4′-Dipyridyl
    Cat. No.
    A97530

    4,4′-Dipyridyl

    4,4′-Dipyridyl is a heterocyclic compound that serves as a versatile bidentate ligand in supramolecular chemistry. This reagent is widely employed as an electronic and photosensitive building block, enabling the development of advanced materials and complex architectures. Additionally, 4,4′-Dipyridyl acts as a critical drug intermediate in the synthesis of paraquat, an extensively used herbicide, facilitating research in agricultural chemistry and environmental science.

    1 g
    $20.00
    10 g
    $25.00
    All 6 sizes
  • Tri(2-methylphenyl)phosphine
    Cat. No.
    A97633

    Tri(2-methylphenyl)phosphine

    Tri(2-methylphenyl)phosphine is an organic phosphorus compound functioning as a ligand that facilitates the formation of metal complexes. Its primary application is as a drug intermediate in pharmaceutical synthesis. The compound's structural characteristics enhance its utility in various coordination chemistry applications, making it a valuable reagent in organic and medicinal chemistry research.

    1 mg
    $20.00
    2 mg
    $25.00
    All 12 sizes
  • LY280748
    Cat. No.
    A98748

    LY280748

    LY280748 is a potent imidazolate receptor ligand, functioning primarily as a drug intermediate. This compound exhibits significant biological activity, making it a valuable tool in pharmacological research and development. Its application spans various studies focused on receptor-mediated signaling pathways and the synthesis of novel therapeutic agents.

    Out of stock

    All 3 sizes
  • Cintriamide
    Cat. No.
    A99692

    Cintriamide

    Synonyms: Cintramide

    Cintriamide is a crucial synthesis intermediate used in the preparation of photoswitchable epothilone-based microtubule stabilizers. Its unique chemical properties facilitate the development of novel compounds targeting microtubule dynamics, making it vital for advancing research in cancer therapeutics and related fields. This compound serves as a valuable building block for scientists exploring new therapeutic avenues in antineoplastic drug development.

    Out of stock

    All 3 sizes

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