Search by product name, CAS, target or catalog number. Press Down Arrow to reach product suggestions, Tab to move between links, and Escape to close suggestions.
Impurities & Reference Standards collects environmental contaminants, industrial chemicals and drug stereoisomers. Many entries are substances monitored in environmental and food analysis, such as the plasticizer dimethyl phthalate and the polycyclic aromatic hydrocarbon fluorene. Flame retardants are represented by the organophosphate triphenyl phosphate and by brominated compounds. Perfluorodecanoic acid belongs to the per- and polyfluoroalkyl substances (PFAS), a class known for persistence in the environment. A second group holds enantiomers and isomers of research compounds, such as (R)-Asundexian, the (R)-enantiomer of the factor XIa inhibitor asundexian. Such isomers support stereochemical comparison and the development of chromatographic separation methods. Process-related and degradation compounds of individual drugs are listed separately under Drug Impurity.
UNC-4219 TFA serves as a methylated negative control for the CBX7-H3 antagonist UNC3866, demonstrating no interaction with the CBX7 protein at high concentrations. This compound is primarily utilized in research applications that assess the specificity and efficacy of CBX7 modulation, providing a valuable reference point in studies involving chromatin modification and gene regulation.
Out of stock
All 3 sizes
(6R)-FR054 is a less active isomer of FR054, acting primarily as a modulator of biological pathways influenced by the parent compound. This reagent provides a valuable tool for comparative studies aimed at elucidating the mechanisms of action and specific contributions of the more active isomer. Researchers can utilize (6R)-FR054 in the development of experimental designs that require an understanding of molecular interactions and signaling processes.
Cetirizine N-oxide is an oxidative degradation product of the histamine H1 receptor antagonist cetirizine. This compound serves as a useful reference in studies investigating the metabolic pathways and stability of cetirizine. Research applications may include pharmacokinetic studies, drug metabolism investigations, and the assessment of oxidative stress impacts on antihistamine efficacy.
WAY-120744 is a novel naphthalenyl 3H-1,2,3,5-oxathiadiazole 2-oxide that acts as a potent modulator of biological targets relevant to chemotherapeutic strategies. This compound demonstrates significant anti-cancer activity, making it suitable for applications in cancer research and drug development. Its unique structure permits exploration of mechanisms of action in various cellular contexts, providing valuable insights into the modulation of signaling pathways.
Fz7-21S is a negative control for the peptide antagonist Fz7-21, targeting FZD7 receptors. This reagent serves as a critical tool in experimental setups that require the evaluation of Fz7-21 activity without exerting its inhibitory effects. It is suitable for studies focused on FZD7-mediated signaling pathways, enabling researchers to delineate the specific biological functions and downstream effects associated with FZD7 receptor inhibition.
(Rac)-MK 0686 is a racemic mixture of MK 0686, which acts as an antagonist of the bradykinin B1 receptor. This compound demonstrates key biological activity by inhibiting bradykinin-induced signaling pathways, making it a valuable tool for research in pain modulation and inflammation. Its applications extend to studying the roles of bradykinin receptors in various physiological and pathological conditions.
Out of stock
All 3 sizes
(R)-SCH-23982 hydrochloride is the R-enantiomer of SCH-23982, a selective antagonist of the dopamine D1 receptor. This compound demonstrates significant potential in the study of central nervous system disorders, including schizophrenia and Parkinson's disease. Its targeted action on dopamine D1 receptors makes it a valuable tool for exploring therapeutic strategies in neuropsychiatric research.
(Rac)-L-659989 is a racemic mixture of the selective and competitive platelet activating factor (PAF) receptor antagonist, L-659989. It exhibits potent oral bioactivity, making it a valuable tool for studying PAF signaling pathways. This compound is utilized in research applications focused on cardiovascular and inflammatory diseases, where PAF receptor modulation plays a critical role.
(Rac)-MEM 1003 is the racemic mixture of MEM 1003, a dihydropyridine derivative that acts as a potent antagonist of L-type calcium channels. This compound has demonstrated significant biological activity in modulating calcium influx, making it a valuable tool in Alzheimer's disease research. (Rac)-MEM 1003 offers potential insights into calcium channel regulation and its implications in neurodegenerative conditions.
W-7 isomer hydrochloride is a selective calmodulin antagonist known for its inhibitory effects on calmodulin-mediated processes. This compound is employed in various biological research applications, particularly in studies related to calcium signaling, muscle contraction, and signal transduction pathways. Its specific targeting of calmodulin makes it a valuable tool for investigating cellular mechanisms influenced by calcium ions.
Synonyms: (Rac)-IAA-94
(Rac)-Methylindazone is the racemic mixture of Methylindazone, a potent blocker of the CLIC1 ion channel. This compound exhibits significant biological activity in modulating chloride ion transport, making it a valuable tool in research focused on ion channel function and related physiological processes. Potential applications include studies in cellular signaling and the investigation of CLIC1's role in various pathophysiological conditions.
Synonyms: (R)-SPD502
NS1219, the isomer of NS1209, serves as a selective AMPA receptor antagonist, exhibiting neuroprotective properties. This compound is utilized in research focusing on stroke, neuropathic pain, and epilepsy, providing insights into potential therapeutic approaches for these conditions. Its unique mechanism and target profile make it a valuable reagent for neurobiology studies.
(R)-ONO-2952 is a highly selective enantiomer of ONO-2952, acting as a potent antagonist of the translocator protein (TSPO) with inhibition constants (Kis) ranging from 0.33 to 9.30 nM for both rat and human TSPO. This compound exhibits a notable selectivity for TSPO over other receptors, transporters, ion channels, and enzymes. Its significant biological activity makes it a valuable tool for research applications focused on neuroinflammation, neuroprotection, and various TSPO-related pathways in cellular and molecular studies.
11alpha-Hydroxyprogesterone is an isomer of 11beta-Hydroxyprogesterone, serving as a valuable experimental control in research. It exhibits biological activity as a modulator of steroid receptors and can be utilized to investigate the effects of glucocorticoids and mineralocorticoids in cellular systems. Its application includes studying the activation of human mineralocorticoid receptors and the inhibition of 11β-Hydroxysteroid dehydrogenase, facilitating a deeper understanding of steroid hormone signaling pathways.
